Yvette Tache, PhD

Professor, Vatche and Tamar Manoukian Division of Digestive Diseases, David Geffen Department of Medicine at UCLA

Dr. Taché is an Associate Director of the CURE: DDRCC and Director of the Animal Models Core. She leads the Brain-Gut Iinteractions Laboratories that focus on the role of brain peptides in the regulation of autonomic outflow to the gut and the mechanisms through which stress--in particular, corticotropin releasing factor (CRF)-- signaling pathways influence digestive function as it relates to gastrointestinal motor function, gastric ulcers, colitis, visceral pain and feeding using electrophysiological, neuroanatomical, molecular and pharmacological approaches. Models of psychological and viscerosensory stress using colonic distention and abdominal surgery are used to dissect the neuronal pathways and neurotransmitters altering. Her research is funded by  NIDDK R01 grants and a VA Merit Award. Her group made pioneering observations that established the physiological role in the brain of several peptides to influence vagal ouflow to the stomach and regulate gastric and colonic function. Dr. Taché also established the role of activation of CRF receptors in the gut responses to stress.