Jonathan Jacobs, MD, PhD

Assistant Clinical Instructor, Division of Digestive Diseases, David Geffen Department of Medicine at UCLA

The human small intestine and colon harbor a complex microbial ecosystem, collectively called the intestinal microbiome. The Jacobs Laboratory studies how intestinal microbes interact with intestinal cells and the immune system to promote inflammatory bowel disease, obesity, and other diseases. This involves a translational approach that combines detailed characterization of the microbiome of human subjects by 16S ribosomal RNA sequencing, metagenomics, and metabolomics and modeling of the effect of disease-associated human microbial communities in humanized gnotobiotic mice (i.e. germ-free mice colonized with human microbiota). The Jacobs Laboratory also operates the CURE-supported UCLA Microbiome Core. This core was established to provide a comprehensive suite of microbiome-related services to support microbiome research by CURE researchers and other members of the UCLA scientific community.

Jacobs Laboratory:
UCLA Microbiome Center:

Jonathan Jacobs
UCLA Med-Div of Digestive Dis
BOX 956949, 44-139 CHS
Los Angeles, CA 90095-6949