Guido Eibl, MD

Professor, Department of Surgery, David Geffen School of Medicine at UCLA

Dr. Eibl research interest has been in elucidating the role of inflammatory processes in pancreatic cancer development and progression. He studies the role of cyclooxygenases (COXs) and eicosanoids in the development and growth of pancreatic cancer using xenograft and transgenic animal models of the disease and human pancreatic cancer cells in culture. He and his colleagues have demonstrated that COX products, in particular PGE2, stimulate pancreatic cancer cell proliferation, invasion, metastasis, and angiogenesis in vitro and in vivo. In addition, Dr. Eibl is interested in the therapeutic and preventive efficacy of omega-3 polyunsaturated fatty acids (fish oil) in pancreatic cancer. In particular, he investigates the anti-inflammatory properties of omega-3 polyunsaturated fatty acids. Dr. Eibl also studies the efficacy of naturally-occurring polyphenolic compounds in pancreatic cancer prevention and therapy using xenograft and genetically engineered animal models of the disease. More recently, Dr. Eibl has focused his interests on diet-induced obesity and promotion of pancreatic cancer development in genetically modified mice harboring oncogenic K-ras in the pancreas.