The Overall Goal of the CURE:DDRCC is to promote disciplinary research in the molecular adn cell biology, physiology and pathophysiology of the digestive system, foster collaboration and facilitate training, education and recruitment of new investigators.  The Pilot and Feasbility Program has also been enhanced by partnering with the UCLA Center for Translational Science (CTSI).  The specific aims of the Pilot and Feasbility Program are :

1. To provide funds for innovative research relevant to the CURE:DDRCC research program leading to extramural funds.

2. To foster the career development of junior investigators in digestive disease research,

3. To recruit individuals from different areas of research non-related to gastroenterology but with expertise that can be applied to digestive diseases research and benefit the CURE:DDRCC members,

4. To facilitate and promote collaboration between CURE:DDRCC members and PFS awardees.

Pilot and Feasibility Awardees 2011-2016

Cynthia Hong, PhD
"Regulation of Intestinal Lipid Metabolism by IDOL"

Kai Fang, PhD
"Regulation of colitis by miR-221-5p and miR-222 3p-neurokinin receptor interactions"

Thomas Vallim, PhD
"Central Rol eof FXR-MAFG in Bile Acid Homeostasis and Inflammation"

Stavroula Baritaki, PhD
"Effects of corticoptrophin releasing hormone receptor 2 (CRHR2) in modulating colon cancer immunoscape through Fas/FasL regulation"

Haofeng Ji, PhD
"Neuroregulation in Hepatic Ischemia/Reperfusion Ijury in Orthotopic liver Transplantation: Immunomodulation via PKA-CREB-KRL4 Pathway"

Timothy Donahue, MD
"Targeting micro RNA 21 in human pancreatic cancer"

Katrin Hacke, PhD
"A novel chemoselection strategy for hematopoetic stem cell transplantation in IBD"

Kathleen Hertzer, MD
"Understaning the link between diet, inflammation and pancreatic cancer"

Christos Polytarchou, PhD
"the role of miR021 expression in ulcerative colitis-associated colorectal cancer initation and progression"

Martin Martin, MD
"Peptidomic survey of regulated hormone secretion from human small intestinal mucosa derived from a sugject with a germ-line mutation of PCSK1"

Guisheng Zhou, PhD
"The molecular mechanism underlying the positive regulation of PDX-1 expression by Notch 1 activation"

Elizabeth Marcus, MD
"Exploitation of Helicobacter pylori adaptive responses to chronic acid exposure to identify novel eradication targets"